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. Author manuscript; available in PMC: 2021 Jan 6.
Published in final edited form as: Nanomedicine. 2019 Mar 1;18:31–43. doi: 10.1016/j.nano.2019.02.007

Figure 1.

Figure 1.

H1650 SP cells have high tumorigenic and migratory potentials, which drive resistance to chemotherapy. (A) H1650 SP suspension cultures were more tumorigenic compared to H1650 MP cells, as well A549 SP and MP cells. (B) H1650 SP adherent cultures readily propagate as spheroids on Lipidure®-coat plates; (C) H1650 SP cells have higher migration rates compared to main population cells; (D) H1650 SP cells exhibit higher resistance potential to 72-h treatment with cisplatin compared to H1650 MP cells; and (E) SOX2 is significantly upregulated in H1650 SP cells compared H1650 MP cells. Statistical analysis: sphere (****P < 0.0001); cell viability, IC50 (**P = 0.0073); cell migration (**P = 0.0024); and SOX2 expression (****P < 0.0001).