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. Author manuscript; available in PMC: 2021 Jan 6.
Published in final edited form as: Nanomedicine. 2019 Mar 1;18:31–43. doi: 10.1016/j.nano.2019.02.007

Figure 4.

Figure 4.

Cationic lipoplex loaded with siSOX2 (CL-siSOX2) inhibit expression of stemness markers in mice xenograft tumors. C.B.17 SCID mice with H1650 SP cells as tumor xenografts received treatment as described. (A) Immunoblotting of tumor lysates show knockdown of (B) SOX2 and associated stemness factors including (C) OCT4, (D) Nanog, (F) KLF4, as well as the oncogene (E) c-Myc. Results were calculated as protein/β-actin ratio and presented as mean percent of the CL-siScr with SD. Statistical analysis: student t test: (treatment vs. siScr: **P < 0.01; ***P < 0.001; ****P < 0.0001, treatment vs. cisplatin: ###P < 0.001; ####P < 0.0001, and treatment vs. CL-siSOX2: †P < 0.05; ††††P < 0.0001).