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Cd70 ablation exacerbates insulitis and accelerates T1D onset in NOD mice. (A) Mean insulitis scores (0 = no insulitis to 4 = no remaining islet cell mass) in 8- to 10-week-old Cd70−/− and Cd70+/+ female NOD mice. Insulitis severity was significantly greater in Cd70−/− than Cd70+/+ mice according to the Mann-Whitney test. (B) The incidence of T1D in female and male littermates of the indicated genotypes. Survival curves were compared by the Log-rank test. ***P < 0.001, *P < 0.05.
