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. 2021 Jan 6;555:35–43. doi: 10.1016/j.virol.2020.12.020

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 4 — Serum cell- and bead-based Spike-ACE2 inhibition rates and authentic virus neutralization titers.

(A) Serum Spike-ACE2 inhibition rates were measured by cell- and bead-based inhibition assays. The inhibition rates of sera from patients (PT) and healthy controls (HC) at 1:20, 1:100, and 1:500 dilution are shown. The line indicates each individual. (B) Serum authentic virus neutralization titers among all patients (PT) and some healthy controls (HC) are shown. (C) The correlations between the authentic virus neutralization titers and the cell- and bead-based Spike-ACE2 inhibition assays are shown. (D) The correlation between the cell-based and bead-based inhibition assay is shown. (E) The correlations between the neutralization titers and antibodies against the SECD, S1, and RBD are shown. Spearman's test.