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The KLF5 gene itself is activated by super-enhancers. The activated KLF5 binds to enhancers and recruits the CBP/EP300 complex to enhance the binding of BRD4. Chromatin loops aggregate the KLF5 binding events to act on promoters of their target genes, which activates POL2 elongation and transcription. The transcription of the KLF5 gene and the activity of the KLF5 protein are sensitive to BRD4 degraders.
