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. 2021 Jan 6;16(1):e0244275. doi: 10.1371/journal.pone.0244275

Table 4. Comparison of clinical factors between GBM patients with different statuses of 2-year survival.

2-year survival P value
< 2 year (n = 25) > 2 year (n = 5)
age (yr) 59.19 59.15 0.697
Sex
Female 11 3 0.642
Male 14 2
Tumor volume (median) (cm3) 36.71 15.92 0.075
Surgical Intervention
Biopsy 9 0 0.061
Subtotal or partial resection 7 0
Total resection 9 5
Initial Treatment
CCRT 20 5 0.566
Chemotherapy or radiation alone 5 0
Follow-up Treatment
Adjuvant Temozolomide
yes 18 5 0.304
no 7 0
Bevacizumab
yes 12 3 1.000
no 13 2
other chemotherapy agents
yes 11 2 1.000
no 14 3
Radiation
yes 4 0 1.000
no 21 5

Note: Values are number of patients unless otherwise indicated. P values were calculated by using non-parametric Wilcoxon rank sum test on continuous data and Fisher exact test on categorical data. GBM, glioblastoma multiforme; CCRT, concurrent chemoradiation therapy with temozolomide.