Table 1.

Potential retinoid therapeutics for AMD-like retinal degeneration.

Compound name	Chemical structure	Protection mechanism	References
C20-D3-vitamin A		• Slowing the rate of all-trans-retinal dimerization • Deceleration of A2E biosynthesis	55–56
Isotretinoin		• Decrease of 11-cis-retinal levels	57–58
N-(4-Hydroxyphenyl) retinamide		• Reversible suppression of the visual cycle	59
Emixustat		• Reversible suppression of the visual cycle	60–62
Retinylamine		• Reversible suppression of the visual cycle	61
11-cis-6-member-retinal		• Prevention of the retinal isomerization • Locking the chromophore within the receptor’s ligand-binding pocket	65