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. 2020 Aug 27;245(17):1552–1559. doi: 10.1177/1535370220950639

Figure 4.

Figure 4.

Arecoline acts on GAR-2/EGL-8 axis in motor neurons to extend lifespan. (a) Survival plots of wild type N2 (blue), gar-2(ok520) (orange), muscle-specific (green), and motor neuron-specific (red) GAR-2-rescued gar-2(ok520) mutants. (b) Survival curves of motor neuron-specific GAR-2-rescued gar-2(ok520) mutants with (green) or without (blue) 0.1 mM arecoline from adult Day 4 to Day 6. P = 0.0302. (c) Survival curves of muscle-specific GAR-2-rescued gar-2(ok520) mutants with (red) or without (blue) 0.1 mM arecoline from adult Day 4 to Day 6. P = 0.2625. (d) Survival curves of egl-8(n488) mutants with vehicle (blue), 0.1 mM arecoline (red, P = 0.5142 against control group) or 0.2 mM arecoline (orange, P = 0.5676 against control group) from adult Day 4 to Day 6. P-values are derived from log-rank test. The graphs are representative of two or three independent experiments. See Table S1 for statistical analysis and additional repeats. (e) A working model for arecoline-induced longevity in aged worms.