Fig. 7.

HA hydrogels enhanced in vivo cartilage repair of hESC-MSCs on MIA osteoarthritis mice. a Schematic illustration of hESC-MSC and HA hydrogel composite transplantation for cartilage repair of MIA osteoarthritis mice. b Clinicopathologic features of osteoarthritis in control mice (Sham) or MIA osteoarthritis mice. c The OARSI macroscopic scores of mice in the indicated groups. d Microscopic structure of cartilage sections with indicated staining, respectively. e–g The histopathological scores of cartilage sections in the indicated mice based on the indicated staining, respectively. h Illustration of the osteoarthritis-associated parameters as shown in Additional file 5: Figure S5a by PCA (Axes F1 and F2 representing 71.50%). For instance, HA/hESC-MSCs (word labeled in blue) and some variables corresponding to F1 (Mankin score and OARSI macroscopic score) (also see Additional file 5: Figure S5a) showed positive correlation, while HA/hESC-MSCs and Sham were opposed with the PBS (F2) (also see Additional file 5: Figure S5a; dot labeled in blue). All data were shown as mean ± SEM (n = 6). *P < 0.05, **P < 0.01; NS, not significant