Table 2.
Multiple imputed effects and costs for the intervention program group (n = 184) and usual care group (n = 110) after 48 weeks.
| Outcomes | Mean (SE) | Mean difference (95% CI)a,b | |
|---|---|---|---|
| Intervention program (n = 184) | Usual care (n = 165) | ||
| Hospital Anxiety and Depression Scale (HADS) score (0–42) | |||
| Baseline | 8.81 (0.24) | 10.31 (0.26) | –0.058 (–0.13 to 0.011)c |
| T1 | 8.72 (0.47) | 10.16 (0.57) | |
| T2 | 8.39 (0.53) | 10.43 (0.65) | |
| T3 | 8.02 (0.59) | 9.89 (0.69) | |
| T4 | 7.76 (0.58) | 9.78 (0.79) | |
| Quality-adjusted life-year (QALY) (0–1) | 0.63 (0.018) | 0.58 (0.020) | 0.042 (–0.015 to 0.099) |
| Healthcare costs | |||
| Primary care | 784 (63) | 725 (67) | 58 (–119 to 233) |
| Mental healthcare | 93 (25) | 110 (25) | –18 (–83 to 56) |
| Home care | 1910 (718) | 2798 (1201) | –888 (–4159 to 1484) |
| Outside hospital | 15 (6) | 19 (7) | –5 (–22 to 12) |
| Treatment costs | 24,356 (614) | 23,892 (696) | 526 (–1155 to 2215) |
| Intervention | 31 (2) | 0 (0) | 31 (28 to 35) |
| Total healthcare costs | 27,189 (916) | 27,545 (1362) | –295 (–3844 to 2579) |
| Non-healthcare costs | |||
| Lost productivity | 2008 (379) | 2301 (421) | –290 (–1389 to 806) |
| Informal care | 2915 (369) | 3482 (565) | –567 (–1890 to 559) |
| Total non-healthcare costs | 4923 (503) | 5784 (680) | –857 (–2411 to 622) |
| Total societal costs | 32,112 (1073) | 33,329 (1627) | –1152 (–5058 to 2214) |
SE: standard error; 95% CI: 95% confidence interval.
Variables included in the multiple imputation model are described in the lower part of the table. Multiple imputation model consisted of variables that differed at baseline (HADS); variables that were related to missingness (Eastern Cooperative Oncology Group score, progression, smoking, gender, education, primary location of cancer, and number of metastases); variables that were associated with the outcome (Eastern Cooperative Oncology Group score, progression, comorbidities, work, type of chemotherapy, number of metastases, primary location of cancer, drinking, smoking, gender, and education).
Corrected for progression.
Uncertainty around cost differences estimated using the non-parametric bootstrap.
Overall effect over time corrected for score on HADS at baseline.