Table 3.
Results of the cost-effectiveness analysis, cost-utility analysis, and sensitivity analyses.
| Outcome | ΔC (95% CI)a,b | ΔE (95% CI)a | ICER | CE plane (%) | |||
|---|---|---|---|---|---|---|---|
| NE | SE | SW | NW | ||||
| Main analysis: Societal perspective | |||||||
| HADS score (0–42) | –1152 (–4595 to 1908) | –0.058 (–0.13 to 0.0095)c | 19,991 | 35 | 60 | 4 | 1 |
| QALYs (0–1) | –1152 (–4631 to 1955) | 0.042 (–0.0094 to 0.094) | –27,277 | 35 | 60 | 4 | 1 |
| SA1: Healthcare perspective | |||||||
| HADS score (0–42) | –295 (–3279 to 2585) | –0.058 (–0.13 to 0.0095)c | 5115 | 47 | 47 | 4 | 2 |
| QALYs (0–1) | –295 (–3254 to 2639) | 0.042 (–0.0098 to 0.094) | –6980 | 47 | 47 | 4 | 2 |
| SA2: Human capital approach | |||||||
| HADS score (0–42) | –2155 (–7900 to 2160) | –0.058 (–0.13 to 0.0095)c | 37,414 | 36 | 58 | 5 | 1 |
| QALYs (0–1) | –2155 (–7940 to 2117) | 0.042 (–0.0098 to 0.094) | –51,051 | 36 | 58 | 4 | 2 |
| SA3: Including training costs | |||||||
| HADS score (0–42) | –1152 (–4595 to 1908) | –0.058 (–0.13 to 0.0095)c | 19,991 | 35 | 60 | 4 | 1 |
| QALYs (0–1) | –1152 (–4632 to 1955) | 0.042 (–0.0098 to 0.094) | –27,277 | 35 | 60 | 4 | 1 |
| SA4: Unadjusted analyses | |||||||
| HADS score (0–42) | –1217 (–4886 to 1933) | –0.057 (–0.12 to 0.0098) | 21,211 | 35 | 60 | 4 | 1 |
| QALYs (0–1) | –1217 (–4846 to 1988) | 0.039 (–0.018 to 0.095) | –31,304 | 33 | 58 | 7 | 2 |
CE plane: cost-effectiveness plane; ICER: incremental cost-effectiveness ratio; NE: northeast quadrant; NW: northwest quadrant; SA: sensitivity analysis; SE: southeast quadrant; SW: southwest quadrant; 95% CI: 95% confidence interval; QALYs: quality-adjusted life-years; HADS: Hospital Anxiety and Depression Scale.
a
Corrected for progression.
b
Uncertainty around cost differences estimated using the non-parametric bootstrap.
c
Overall effect over time corrected for score on HADS at baseline.