Table 2. Upstream regulator analysis in CCC myocardium.
| Upstream Regulator | Molecule | Activation z-score | p-value of overlap |
|---|---|---|---|
| IFNG | cytokine | 7.891 | 2.38E-24 |
| TNF | cytokine | 6.494 | 2.19E-12 |
| IL18 | cytokine | 4.583 | 8.95E-14 |
| NFkB (complex) | complex | 4.465 | 5.54E-06 |
| CD40LG | cytokine | 4.287 | 4.10E-15 |
| TCR | complex | 3.832 | 1.80E-26 |
| BCR (complex) | complex | 3.771 | 1.27E-15 |
| IL7 | cytokine | 3.466 | 6.32E-18 |
| TET2 | enzyme | 3.357 | 4.04E-03 |
| IL4 | cytokine | 3.082 | 7.43E-23 |
| EBI3 (IL27Rβ chain IL27RB) | cytokine | 2.785 | 2.13E-05 |
| Fcer1 | complex | 2.72 | 3.35E-05 |
| CXCL10 | cytokine | 2.581 | 3.15E-04 |
| Ap1 | complex | 2.454 | 5.70E-03 |
| CCL5 | cytokine | 2.432 | 5.92E-03 |
| U1 snRNP | complex | 2.384 | 1.24E-06 |
| TNFSF14 (LIGHT) | cytokine | 2.224 | 9.77E-03 |
| PI3K (complex) | complex | 2.007 | 3.62E-04 |
| Collagen type I | complex | 2.000 | 3.96E-01 |