Figure 1.
Huaier extract reduces renal damage and fibrosis and upregulates miR-1271 during AKI-CKD transition. (a) Serum creatinine level over time. (b) Photomicrographs of kidney sections 28 days after ischemia-reperfusion injury (IRI) (hematoxylin-eosin staining). Scale bars: 100 μm (×200) or 50 μm (×400). (c) Relative expression of miR-1271 by real-time PCR. (d) Photomicrographs of kidney sections showing collagen deposition 28 days after IRI (Masson trichrome staining). ∗P < 0.05; ∗∗P < 0.01 (vs. the sham group); #P < 0.05; ##P < 0.01 (vs. the IRI group).