Table 6.
Identification of the druggability cavities obtained by DoGSiteScorer.
| Protein | Volume (angstrom3) | Surface area (angstrom2) | Drug score | Residues |
|---|---|---|---|---|
| RNA editing complex protein M18 | 1494.7 | 2197.05 | 0.81 | VAL28, GLY29, VAL30, VAL31, HIS32, ASP33, ILE34, GLN35, THR45, GLN46, PHE47, THR48, THR50, THR51, THR52, LYS67, HIS69, ILE72, CYS74, PHE79, VAL83, LYS84, GLN85, LYS86, VAL87, LYS88, GLU89, GLY90, ASN91, VAL92, VAL93, VAL95, ASN9, VAL120, GLN126, VAL127, VAL129, HIS131, GLY132, ASP133, ARG134, ARG135, ASN136, THR137, PRO138, VAL139, SER140, VAL141, ASN142, PRO143, THR144, ALA145, GLU146 |
| Hypothetical protein TCDM_03925 | 1131.67 | 1451.37 | 0.81 | GLU235, ARG238, GLY239, GLU240, LEU241, ARG242, GLY245, CYS246, VAL247, ALA248, HIS300, THR337, VAL338, ASP339, PRO340, THR341, ALA342, VAL343, GLU394, LEU395, GLY396, SER397, ARG398, LEU399, GLY444, SER446, PRO503, MET504, GLN505, ARG506, LEU579, GLY582, LYS583, LEU585, LYS586, LEU587, LEU588, TYR589, SER590, PRO591, GLU596, PRO597, ARG598, ASN599, VAL600, PHE602, TYR603, SER604, GLU605, ALA607, ALA608, ILE610, GLU611, ALA639, ARG640, ARG641, PHE642, ALA659 |
| Inosine-guanine nucleoside hydrolases | 794.5 | 907.63 | 0.81 | ASP11, GLY13, GLY14, ASP15, ASP16, ASN40, VAL41, THR77, VAL78, GLN79, TRP80, GLY81, GLY82, PHE83, GLY84, ARG85, ASP86, GLY87, LEU131, GLY132, PRO133, MET162, ASN171, SER172, GLU177, PHE178, ASN179, TRP205, TRP215, PHE247, LEU250, THR254, ASP273, THR275, CYS276, VAL277, ILE278, PRO279, ASP280 |
| Mitochondrial RNA-binding protein 1 | 858.62 | 1230.81 | 0.82 | ILE34, HIS35, ASP36, ARG38, PRO41, ALA42, LEU43, GLY44, THR45, MET46, THR47, GLN60, TYR61, PRO62, GLN63, LEU64, GLY65, ASP79, ASP81, ARG82, ILE84, ILE131, HIS132, ARG133, VAL134, ALA135, SER136, LYS138, GLU140, ASP141, TRP142, SER143, VAL144, ASN145, PHE146, ASP147, LYS148, PHE150 |
| Calpain-like cysteine peptidase | 213.06 | 409.93 | 0.27 | SER6, SER7, THR8, SER9, GLU32, ILE34, GLY35, SER38, GLU42, THR43, GLY44, GLU45 |
| Trans-sialidase | 431.81 | 805.62 | 0.72 | THR22, SER99, GLY100, GLY101, ALA102, GLY103, VAL104, PHE113, PRO114, TYR151, PRO152, ARG153, VAL154, THR155, LEU162, MET163, SER164, VAL165, ASP166, ARG172, VAL173, LEU190, TRP194, LYS206 |