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. 2020 Dec 7;2020:5728674. doi: 10.1155/2020/5728674

Table 1.

Novel therapeutic approaches to diabetic retinal neurodegeneration in experimental studies.

Anti-inflammatory substances Antioxidants Neurotrophins and other neuroprotective factors Mixed or unknown mechanisms
Alpha-1-antitrypsin Fenofibrate and other PPARα agonists Somatostatin Flavonoids and other nutraceuticals
Citicoline Inhibitors of protein tau hyperphosphorylation: ginsenoside Rg1 Notoginsenoside R1 siRNA Ciliary neurotrophic factor Angiotensin II type 1 receptor blockers
Fluocinolone acetonide Spermine oxidase inhibitors Sigma1 receptor Angiotensin-converting enzyme 2 activators
Caffeic acid alkyl amide derivatives Synthetic microneurotrophin BNN27 GLP-1 receptor agonists
Taurine Brain-derived neurotrophic factor Lamivudine
Gabapentin Eicosapentaenoic acid ethyl ester Endothelin-1 receptor antagonists
Acrolein-scavenging 2-HDP Intravitreal bone marrow CD133+ stem cells transplantation Intraocular pressure-lowering agents
Astaxanthin