Table 1.

Demographic data and prior medical history of COVID positive patients with mild, moderate, and severe encephalopathy, all encephalopathy cases, and cases without encephalopathy

	Mild	Moderate	Severe	Encephalopathy cases	Cases without encephalopathy	P value
Number of cases	12	18	13	43	12	-
Men	8 (67%)	12 (67%)	9 (69%)	29 (68%)	6 (50%)	0.17*
Age (years)	58.5 (+/− 15.9)	65.1 (+/− 12.9)	58.2 (+/− 15.8)	61.2 (+/− 14.7)	55.0 (+/− 9.8)	0.15*
Over 60 years of age	5 (33%)	11 (61%)	7 (54%)	22 (51%)	3 (25%)	-
Days from initial respiratory symptoms to admission	7.0 (5.0–12.0)	2.5 (1.3–4.8)	5.0 (1.0–7.0)	3.5 (2.0–7.8)	6.5 (4.5–8.0)	-
Days from admission to initial neurology consultation	4.0 (1.5–6.0)	10.0 (3.3–19.8)	6.0 (2.0–10.0)	5.0 (3.0–16.0)	11.5 (3.3–21.8)	-
Prior medical history
Hypertension	9 (75%)	14 (78%)	8 (62%)	31 (72%)	8 (67%)	0.61*
Diabetes	6 (50%)	8 (44%)	5 (39%)	19 (44%)	4 (33%)	0.92*
Heart disease	4 (33%)	2 (11%)	2 (15%)	8 (19%)	0 (0%)	0.68**
Pulmonary disease	0 (0%)	2 (11%)	2 (15%)	5 (11%)	1 (8%)	0.52**
Impaired renal function	3 (25%)	4 (22%)	4 (31%)	11 (26%)	3 (25%)	0.76**
Alcohol abuse	2 (17%)	1 (6%)	1 (8%)	4 (9%)	0 (0%)	0.96**
Smoking	1 (8%)	4 (22%)	5 (39%)	10 (23%)	2 (17%)	0.19**
Cancer (in the previous 5 years)	0 (0%)	2 (11%)	3 (23%)	5 (12%)	2 (17%)	0.40**
Immuno-suppressive drug use	1 (8%)	0 (0%)	3 (23%)	4 (9%)	3 (25%)	0.78**
Prior neurologic disease	6 (50%)	5 (28%)	3 (23%)	14 (33%)	4 (33%)	0.33**
Ischemic stroke	4 (33%)	3 (17%)	1 (8%)	8 (19%)	0 (0%)	0.97**
Epilepsy	3 (25%)	0 (0%)	1 (8%)	4 (9%)	3 (25%)	0.06**
Dementia	3 (25%)	1 (6%)	1 (8%)	5 (12%)	0 (0%)	0.93**

Data are median (interquartile range), mean (standard deviation) or n/N (%)

*Primary analysis, ordinal logistic regression

**Exploratory analysis, Mann-Whitney test