Table 6.

Normalized thalamus volume measurements and summary of results of the binary logistic regression analysis for cognitively impaired versus cognitively preserved MS patients^a.

	Thalamic volumes			Binary logistic regression
	CP (n = 35)	CI (n = 22)	p-Value	OR	95% Conf int. for OR	p-Value
Normalization SIENAXb
Manual outlines
Left thalamus (mL)	8.99 ± 1.37	8.24 ± 2.31	0.18	0.85	0.66 – 1.11	0.23
Right thalamus (mL)	9.06 ± 1.31	7.91 ± 2.18	0.033	0.72	0.52 – 0.95	0.018
Freesurfer
Left thalamus (mL)	9.02 ± 1.18	8.11 ± 1.44	0.012	0.64	0.42 – 0.99	0.047
Right thalamus (mL)	8.59 ± 1.07	7.54 ± 1.37	0.002	0.53	0.37 – 0.78	0.001
FSL-first
Left thalamus (mL)	10.13 ± 0.94	9.05 ± 1.45	0.004	0.51	0.40 – 0.66	<0.001
Right thalamus (mL)	9.92 ± 0.83	8.90 ± 1.44	0.005	0.49	0.35 – 0.68	<0.001
CAT12
Left thalamus (mL)	5.34 ± 1.38	4.09 ± 1.93	0.012	0.61	0.51 – 0.72	<0.001
Right thalamus (mL)	5.38 ± 1.14	4.17 ± 1.95	0.013	0.58	0.48 – 0.71	<0.001
GIF
Left thalamus (mL)	7.68 ± 0.70	7.17 ± 1.04	0.05	0.55	0.34 – 0.88	0.013
Right thalamus (mL)	7.63 ± 0.63	7.08 ± 1.05	0.033	0.49	0.31 – 0.79	0.003
VolBrain
Left thalamus (mL)	7.02 ± 1.03	5.85 ± 1.48	0.003	0.51	0.41 – 0.63	<0.001
Right thalamus (mL)	6.99 ± 0.90	5.77 ± 1.44	0.001	0.44	0.34 – 0.58	<0.001
Fraction of eTIV Freesurferc
Freesurfer
Left thalamus (10−3)	4.71 ± 0.57	4.20 ± 0.63	0.003	0.27	0.11 – 0.68	0.005
Right thalamus (10−3)	4.49 ± 0.55	3.91 ± 0.61	0.003	0.17	0.05 – 0.61	0.006

Abbreviations CI = cognitively impaired; Conf int = confidence interval; CP = cognitively preserved; OR = odds ratio. ^a Data are mean (SD) for normally distributed variables; ^b Thalamic volumes were multiplied by the head-normalization factor derived from SIENAX; ^c Thalamus volumes were divided by the estimated total intracranial volume (eTIV) from FreeSurfer; p-values in bold represent significant values.