Table 4.
Leave-one-out regression modeling.
| Model Parameters (Removed) | LEL | LOAEL | ||||
|---|---|---|---|---|---|---|
| MSE | % exp. | p-value | MSE | % exp. | p-value | |
| All | 0.347 | 62.1 | 0.258 | 67.4 | ||
| (Chemical) | 0.766 | 16.4 | 1.03e-229 | 0.683 | 13.8 | 9.86e-303 |
| (Strain group) | 0.401 | 56.2 | 4.57e-54 | 0.301 | 62.0 | 1.96e-58 |
| (Study type) | 0.371 | 59.5 | 2.69e-30 | 0.272 | 65.7 | 3.72e-25 |
| (Adm method) | 0.350 | 61.8 | 1.25e-03 | 0.258 | 67.4 | 5.90e-02 |
| (Dose spacing) | 0.350 | 61.8 | 2.27e-05 | 0.259 | 67.3 | 3.11e-03 |
| (Dose number) | 0.351 | 61.7 | 1.46e-06 | 0.258 | 67.4 | 6.65e-01 |
| (Study year) | 0.347 | 62.1 | 7.69e-01 | 0.258 | 67.4 | 5.08e-01 |
| (Substance purity) | 0.347 | 62.1 | 1.98e-01 | 0.258 | 67.4 | 4.94e-01 |
| (Study source) | 0.348 | 62.0 | 3.62e-02 | 0.259 | 67.3 | 8.06e-03 |
| (Sex) | 0.349 | 61.9 | 5.71e-04 | 0.258 | 67.4 | 3.79e-01 |
The full MLR dataset was used for leave-one-out regression modeling of LEL and LOAEL values. MSE (in units of (log10(mg/kg/day))2, estimate of unexplained variance) and the p-value for the covariate based on ANOVA for the MLR models are provided. The α was set to 0.05 for the ANOVA. % exp = percent total variance explained.