Table 3.
Parameter (units) | Control 0 mg/kg bw/d |
Low-dose 100 mg/kg bw/d |
Mid-dose 500 mg/kg bw/d |
High-dose 1000 mg/kg bw/d |
---|---|---|---|---|
Absolute organ weight (g) | ||||
Body weight | 487.10 ± 24.15 | 501.80 ± 30.44 | 492.00 ± 16.87 | 497.20 ± 39.35 |
Liver | 15.029 ± 1.372 | 15.615 ± 1.392 | 15.461 ± 1.877 | 15.983 ± 1.567 |
Kidneys | 3.721 ± 0.358 | 3.753 ± 0.314 | 3.544 ± 0.335 | 3.681 ± 0.217 |
Spleen | 0.812 ± 0.098 | 0.866 ± 0.118 | 0.819 ± 0.132 | 0.874 ± 0.107 |
Brain | 2.039 ± 0.074 | 2.029 ± 0.082 | 2.059 ± 0.153 | 2.084 ± 0.107 |
Heart | 1.341 ± 0.148 | 1.406 ± 0.117 | 1.375 ± 0.151 | 1.395 ± 0.162 |
Thymus | 0.326 ± 0.080 | 0.284 ± 0.048 | 0.320 ± 0.063 | 0.303 ± 0.047 |
Adrenals | 0.0781 ± 0.0132 | 0.0885 ± 0.0124 | 0.1010 ± 0.0187* | 0.0881 ± 0.0239 |
Thyroid gland | 0.0360 ± 0.0073 | 0.0429 ± 0.006 | 0.0390 ± 0.0071 | 0.0401 ± 0.0097 |
Testes | 4.011 ± 0.315 | 4.376 ± 0.197* | 4.071 ± 0.273 | 4.217 ± 0.459 |
Prostate | 1.1245 ± 0.2517 | 1.0828 ± 0.2559 | 1.1305 ± 0.3797 | 0.8142 ± 0.2029* |
Epididymides | 1.648 ± 0.122 | 1.719 ± 0.089 | 1.680 ± 0.099 | 1.593 ± 0.121 |
Relative organ to body weight ratio | ||||
Liver | 30.930 ± 3.370 | 31.128 ± 2.260 | 31.379 ± 3.234 | 32.167 ± 2.185 |
Kidneys | 7.660 ± 0.876 | 7.476 ± 0.346 | 7.196 ± 0.534 | 7.420 ± 0.358 |
Spleen | 1.668 ± 0.205 | 1.722 ± 0.162 | 1.662 ± 0.245 | 1.755 ± 0.118 |
Brain | 4.196 ± 0.269 | 4.053 ± 0.221 | 4.193 ± 0.390 | 4.215 ± 0.407 |
Heart | 2.756 ± 0.303 | 2.809 ± 0.278 | 2.794 ± 0.300 | 2.819 ± 0.368 |
Thymus | 0.671 ± 0.169 | 0.564 ± 0.075 | 0.651 ± 0.118 | 0.612 ± 0.095 |
Adrenals | 0.1606 ± 0.0279 | 0.1767 ± 0.0255 | 0.2046 ± 0.0336* | 0.1771 ± 0.0441 |
Thyroid gland | 0.0742 ± 0.0158 | 0.0856 ± 0.0124 | 0.0792 ± 0.0141 | 0.0812 ± 0.0215 |
Testes | 8.252 ± 0.784 | 8.739 ± 0.477 | 8.282 ± 0.601 | 8.512 ± 0.996 |
Prostate | 2.3048 ± 0.4891 | 2.1733 ± 0.5643 | 2.2915 ± 0.7360 | 1.6367 ± 0.4078* |
Epididymides | 3.393 ± 0.339 | 3.435 ± 0.233 | 3.417 ± 0.233 | 3.215 ± 0.284 |