Table 5.
Microscopic findings in rats following treatment with Phytase TSP concentrate for 90 days.
| Parameter | Control 0 mg/kg bw/d |
Low-dose 100 mg/kg bw/d |
Mid-dose 500 mg/kg bw/d |
High-dose 1000 mg/kg bw/d |
||||
|---|---|---|---|---|---|---|---|---|
| M | F | M | F | M | F | M | F | |
| KIDNEYS | ||||||||
| - cortical cyst | 1 | – | / | / | / | / | – | – |
| - cortical scar | – | – | / | / | / | / | – | 1 |
| mineralisation | – | 1 | / | / | / | / | – | – |
| - hyaline casts | 4 | 4 | / | / | / | / | 4 | 1 |
| - hydronephrosis | 2 | – | / | / | / | / | – | – |
| - venostasis | 1 | – | / | / | / | / | – | – |
| LARYNX | ||||||||
| - edema | 9 | 9 | / | / | / | / | 8 | 6 |
| - chronic inflammation | 8 | 3 | / | / | / | / | 5 | 3 |
| LIVER | ||||||||
| - focal chronic inflammation | 1 | – | / | / | / | / | – | – |
| LUNGS | ||||||||
| - blood aspiration | – | – | / | / | / | / | – | 1 |
| - focal lipidosis | 4 | 3 | / | / | / | / | 1 | – |
| LYMPH NODES (CERVICAL) | ||||||||
| - hemorrhage | – | – | / | / | / | / | 1 | – |
| - hyperplasia | – | 1 | / | / | / | / | 1 | – |
| PITUITARY GLAND | ||||||||
| - cyst | 1 | 1 | / | / | / | / | – | – |
| PROSTATE GLAND | ||||||||
| - focal chronic inflammation | – | NA | / | / | / | / | 1 | NA |
| - purulent inflammation | 2 | NA | / | / | / | / | – | NA |
| SPINAL CORD | ||||||||
| - hemorrhage | 1 | 4 | / | / | / | / | 4 | 2 |
| SPLEEN | ||||||||
| - extramedullary hemopoiesis | – | – | / | / | / | / | – | 1 |
| - siderosis | – | 3 | / | / | / | / | – | 4 |
| TESTES | ||||||||
| - tubular atrophy | – | NA | / | / | / | / | – | NA |
| THYMUS | ||||||||
| - cyst | – | – | / | / | / | / | – | 1 |
| - focal hemorrhage | – | 1 | / | / | / | / | – | – |
| UTERUS | ||||||||
| - mucosal cyst | NA | – | NA | / | NA | / | NA | 2 |
| - hydrometra | NA | 4 | NA | / | NA | / | NA | 1 |
Preserved organs and tissues from 10 control and 10 high-dose animals and all gross lesions noted in any test groups at time of sacrifice were examined. - = organ examined, no pathology findings; / = organ not examined; NA = Not Applicable.