Figure 6.

The disrupted mitochondrial ultrastructure and the altered genes related to mitochondrial metabolism are recovered by anti-miR-199a treatment

(A) Representative transmission electron microscopy (TEM) images in control, cardiac hypertrophy mice, and the anti-miR-199a-treated mice. Scale bars, 500 nm. Arrowhead, normal mitochondrial ultrastructure; arrow, disrupted mitochondrial ultrastructure (n = 3). (B) The expression of representative genes in glycolysis in each mouse group (n = 8). (C) The expression of representative genes in fatty acid oxidation (FAO) in each mouse group (n = 8). (D) The expression of important transcription factors involved in the mitochondrial metabolism in each mouse group (n = 8). (E) Representative western blot results and the relative protein expression of ERRα and PGC-1α in each mouse group (n = 6). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.