. 2020 Nov 17;23:406–417. doi: 10.1016/j.omtn.2020.11.007

Table 1.

Predicted targets of miR-199a in cardiac hypertrophy

Predicted target gene	Representative transcript in Mus musculus	Gene name	Site in untranslated regions (UTR) (Lower row is the sequence of mmu-miR-199a)	Reported pathway in cardiac hypertrophy and heart failure
Ppargc1a	NM_008904.2	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Position 1518-1525 of Ppargc1a 3' UTR	mitochondrial biogenesis²⁸, cardiac metabolic remodeling²⁵
Dyrk1a	NM_001113389.1	dual specificity tyrosine-phosphorylation-regulated kinase 1A	Position 1547-1554 of Dyrk1a 3' UTR	the Calcineurin-NFAT Pathway⁴¹
Sirt1	NM_001159589.2	sirtuin 1	Position 451-457 of Sirt1 3' UTR	the ERR transcriptional pathway⁴²
Hif1a	NM_001313919.1	hypoxia inducible factor 1 subunit alpha	Position 237-243 of Hif1a 3' UTR	HIF1α-PPARγ glycolytic and lipid anabolic pathways⁴³
Ppard	NM_011145.3	peroxisome proliferator activated receptor delta	Position 902-908 of Ppard 3' UTR	cardiac glucose utilization and metabolic regulatory⁴⁴
Gsk3b	NM_001347232.1	glycogen synthase kinase 3 beta	Position 61-67 of Gsk3b 3' UTR	mToR signaling and inhibit autophagy pathway⁴⁵
Gsk3b	NM_001347232.1	glycogen synthase kinase 3 beta	Position 3781-3787 of Gsk3b 3' UTR	mToR signaling and inhibit autophagy pathway⁴⁵