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. 2020 Oct 9;80(1):109–117. doi: 10.1136/annrheumdis-2020-218636

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Pathway SLE polygenic risk scores grouping and clustering. (A, B) The Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) damage index for patients with SLE positive and negative for the T cell receptor and B cell receptor signalling pathways. P values represent differences in Damage Index between pathway positive and negative patients, uncorrected p values are presented (Bonferroni corrected threshold p=0.00143). (C) Prevalence of Sjögren’s syndrome (SSA and/or SSB) autoantibodies in SLE patients in the four clusters. P value represent difference in SSA/SSB autoantibody status between clusters of SLE patients, uncorrected p value is presented (Bonferroni corrected threshold p=0.002).