Table 3.
The effects of synthetic tryptanthrin agent on tail immersion, hot plate (as thermal stimuli), and acetic acid induced writhing (as chemical stimulus) induced pain responses in mice.
| Compounds | Doses (mg/kg) | Tail immersion (sec) | Hot plate reaction (sec) | Acetic acid induced writhing |
|---|---|---|---|---|
| Negative control (DMSO) | 0.3 mL | 1.7 ± 0.30 | 8.9 ± 0.57 | 51.0 ± 6.08 |
| Tryptanthrin | 6 12 24 |
2.69 ± 0.78 2.08 ± 0.33 2.46 ± 0.64 |
11.38 ± 2.67∗ 14.96 ± 2.64∗ 17.50 ± 2.68∗∗ |
75.40 ± 9.85 60.80 ± 8.19 20.60 ± 3.49∗∗ |
| Acetysalicyclic acid | 100 | 4.5 ± 0.30∗ | 16.2 ± 2.90∗∗ | 19.6 ± 0.80∗∗ |
Values represent means ± SEM of 5 animals ∗p < 0.05, ∗∗p,0.01.