Table 2.
Summary of correlations between SARS-CoV-2 entry-related gene expression and asthma-associated gene signatures
| Asthma-associated gene signature | ||||||
|---|---|---|---|---|---|---|
| IL13 Th2 | Eosinophils | Th17 | Neutrophil | IL-6-TS | Inflammasome | |
| Sputum, n = 120 | ||||||
| ACE2 | r = 0.38*** | r = 0.18* | r = − 0.23* | r = 0.02 | r = 0.14 | r = 0.07 |
| TMPRSS2 | r = 0.57*** | r = 0.15 | r = − 0.06 | r = 0.03 | r = 0.02 | r = 0.10 |
| FURIN | r = 0.10 | r = 0.13 | r = − 0.16 | r = 0.51*** | r = 0.54*** | r = 0.49*** |
| Bronchial brushing, n = 149 | ||||||
| ACE2 | r = 0.12 | r = − 0.07 | r = − 0.11 | r = 0.0005 | r = 0.11 | r = 0.20* |
| TMPRSS2 | r = 0.36*** | r = − 0.04 | r = − 0.10 | r = − 0.06 | r = − 0.07 | r = − 0.06 |
| FURIN | r = 0.30*** | r = 0.14 | r = 0.10 | r = 0.24** | r = 0.30*** | r = 0.30*** |
| Bronchial biopsy, n = 108 | ||||||
| ACE2 | r = 0.23* | r = 0.02 | r = − 0.12 | r = − 0.11 | r = 0.01 | r = 0.14 |
| TMPRSS2 | r = 0.37*** | r = − 0.14 | r = − 0.30** | r = − 0.14 | r = − 0.01 | r = − 0.01 |
| FURIN | r = 0.33*** | r = 0.26** | r = 0.06 | r = 0.20* | r = 0.23* | r = 0.15 |
Association of ACE2, TMPRSS2, and FURIN expression with asthma-associated gene signatures were measured and tested using Spearman’s rank-order correlation. Statistically significant correlations are marked bold and also indicated as follows: *p < 0.05; **p < 0.01; ***p < 0.001. Otherwise non-significant (p > 0.05). IL-6-TS, IL-6-trans-signalling