Table 1.

Author’s recommendation summary

HCLQ hydroxychloroquine, CLQ chloroquine, AZT azithromycin, LPV/r: lopinavir/ritonavir, RDV remdesivir, FAV favipiravir, TCZ tocilizumab, BAR baricinitib, ANK anakinra

TdP Risk: Risk Categories for Drugs that prolong QT and induces Torsade de Pointes (TdP): Known Risk of TdP (these drugs prolong the WT interval and are clearly associated with a known risk of TdP, even when taken as recommended), Possible Risk of TdP (these drugs can cause QT prolongation but currently lack evidence for risk of TdP when taken as recommended), Conditional Risk of TdP (these drugs are associated with TdP but only under certain conditions of their use (e.g., excessive dose, in patients with conditions such as hypokalemia, or when taken with interacting drugs) or by creating conditions that facilitate or induce TdP (e.g., by inhibiting metabolism of QT-prolonging drugs or by causing an electrolyte disturbance that induce TdP), Not classified (this drug has been reviewed but the evidence available at this time did not result in a decision for it to be placed in any of the four QT risk categories. This is not an indication that this drug is free of a risk of QT prolongation or Torsade de Pointes since it may not have been adequately tested for these risks in patients) according to CredibleMeds®

Risk Rating: Zone Red: Not recommended, Zone Orange: Potential interaction which may require a dose adjustment, close monitoring, choosing alternative agents in 2 or more database, Zone Yellow: Potential interaction likely to be of weak intensity. Additional action/monitoring or dose adjustment unlikely to be required in 2 or more database, Zone Green: Little to no evidence of clinically significant interaction expected in 2 or more database

△The most conservative approach. There is not enough information to assign the antipsychotic to any of the previous categories. This recommendation to be taken with caution; (*) Only classified in one database but in this category

Type of interaction: ♥♥ QT-Prolonging agents in 2 or more database, ♥ QT-Prolonging agents in 1 database; ↑/↓ Potential increased/decreased exposure of APs; ⇧Potential increased exposure of COVID-19 treatment; § Hematological risk