Table 3.

Drug-drug interaction between antipsychotics and lopinavir/ritonavir

(1) Avoid products containing alcohol (LOP/RIT) in patients treated with methotrimeprazine

♥♥ QT-Prolonging agents in 2 or more database, ♥ QT-Prolonging agents in 1 database. ❍: No database reports additive effects on QT-interval prolongation

↑/↓ Cytochrome P450 interaction (or UGT1A4 or P-glycoprotein/ABCB1 when correspond). Antipsychotic levels may increase/decreased and dose adjustment may be necessary

*Since ritonavir should be considered as CYP450 pan-inducer some of the information listed in this table, which has been attained from the reported data base, may differ if a more thorough and pertinent analysis of the literature on specific ritonavir-AP DDIs would be performed