Table 3.

Outcome of postprandial combined HRM and pH-impedance monitoring of treated achalasia patients with (RS+) and without reflux symptoms (RS−)

	Patients with reflux symptoms (RS+)	Patients without reflux symptoms (RS−)	P value
	(n=19)	(n=19)
Postprandial combined HRM and pH-impedance measurement
Presence acid exposure (n (%))	5/19 (26)	2/19 (11)	0.41
Acid exposure time (AET: % of time pH <4; mean (95% CI)	1.9 (−1.06 to 4.85)	2.6 (−2.67 to 7.87)	0.81
Acidification patterns (% of time; mean (95% CI))
Acid reflux with normal clearance	0.3 (−0.06 to 0.78)	0 (0 to 0)	0.09
Acid reflux with delayed clearance	1.4 (−1.48 to 4.18)	2.5 (−2.78 to 7.80)	0.69
Acid fermentation	0 (0 to 0)	0 (0 to 0)	1
Stasis of ingested acidic food	0 (0 to 0)	0 (0 to 0)	1
Unclassified	0.2 (−0.21 to 0.60)	0 (0 to 0)	0.53
No of acidification events (median (IQR))
Acid reflux with normal clearance	0 (0–2)	0 (0–0)	0.04
Acid reflux with delayed clearance	0 (0–1)	0 (0–1)	0.97
Acid fermentation	0 (0–0)	0 (0–0)	1
Stasis of ingested acidic food	0 (0–0)	0 (0–0)	1
Unclassified	0 (0–1)	0 (0–1)	0.32
No of patients per acidification pattern (n (%))
Acid reflux with normal clearance	4 (21)	0 (0)	0.04
Acid reflux with delayed clearance	1 (5)	1 (5)	1
Acid fermentation	0 (0)	0 (0)	1
Stasis of ingested acidic food	0 (0)	0 (0)	1
Unclassified	1 (5)	0 (0)	0.32
No of symptoms (median (IQR))	0 (0–1)	0 (0–0)	0.02

AET, acid exposure time; HRM, high-resolution manometry.