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. 2020 May 21;70(1):30–39. doi: 10.1136/gutjnl-2020-320772

Table 4.

Results of oesophageal function tests, endoscopy and questionnaires in treated achalasia patients with (RS+) and without reflux symptoms (RS–)

Patients with reflux symptoms (RS+) Patients without reflux symptoms (RS–-) P value
(n=19) (n=19)
High-resolution manometry
 Basal LOS pressure (mm Hg, median (IQR)) 3 (2–6) 3 (3–6) 0.88
 Integrated relaxation pressure (mm Hg, median (IQR)) 6.2 (2.1–8.7) 5.9 (4.1–9) 0.87
Classification of oesophageal contractility 1
 Failed contractility (n (%)) 13 (68) 13 (68)
 Weak contractility (n (%)) 6 (32) 6 (32)
OGJ distensibility (at 50 mL: mm2/mm Hg, median (IQR)) 5.3 (4.5–6.9) 5.3 (4.5–6.9) 0.18
Timed barium oesophagogram
 Barium column at 5 min (cm, median (IQR)) 1 (0–2) 1.8 (0–2.5) 0.34
 Barium column at 2 min 1.6 (0–2) 2.4 (1–3.5) 0.1
 Oesophageal diameter (cm, median (IQR)) 2.1 (1.8–3) 2.5 (2–3.4) 0.12
Endoscopy
Reflux oesophagitis (n (%)) 10 (53) 4 (21) 0.91
 Grade A 5/10 (50) 2/4 (50)
 Grade B 5/10 (50) 2/4 (50)
Questionnaires (median (IQR))
RDQ total score* 1.9 (1.4–3.3) 0.3 (0–0.6) <0.001
 Heartburn 3 (2–4.3) 0 (0–1) <0.001
 Regurgitation 1 (0.8–2.8) 0 (0–0.3) <0.001
 Dyspepsia 1.8 (0–4) 0 (0–0.5) <0.002
 GORD 2.1 (1.5–2.8) 0.3 (0–0.8) <0.001
Achalasia-DSQoL† 19 (14–22) 13 (12–16) <0.005
SF-36‡
 Physical component summary score 51 (46–55) 54 (51–58) 0.06
 Mental component summary score 57 (53–60) 54 (53–58) 0.37

*RDQ: 12-item questionnaire, providing a score for each typical reflux symptom on a Likert scale, range 0 to5. Per domain the mean score was calculated per patient.

†Achalasia-DSQoL: quality of life related to achalasia, range 10 to 33, lower score indicated better quality of life.

‡SF-36 score consisted of a physical and mental component summary score, each ranged from 0 to 100, with higher scores indicating better quality of life.

DSQoL, Disease-Specific Quality-of-Life questionnaire; GORD, gastro-oesophageal reflux dimension; LOS, lower oesophageal sphincter; OGJ, oesophagogastric junction; RDQ, Reflux Disease Questionnaire; SF-36, 36-item Short-Form Health Survey.