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. 2020 Sep 12;11(2):407–431. doi: 10.1016/j.jcmgh.2020.09.003

Figure 1.

Figure 1

Bioinformatics analysis between FAP, CD29, and periostin gene expression and clinical relevance in liver cancer. (A–C) Gene expression of CAF markers FAP, CD29, and periostin in tumors compared with paired adjacent tumor-free liver tissues in our HCC cohort (N = 75 HCC, Mann–Whitney U tests). ∗∗∗P < .001. (D, I, and N) Gene expression of CAF markers FAP, CD29, and periostin in CCA compared with normal liver tissues in an online TCGA database (n = 9 for normal liver tissue, n = 36 for tumor tissue; 1-way analysis of variance). ∗P < .05. (F, K, and P) Gene expression of CAF markers FAP, CD29, and periostin in HCC compared with normal liver tissues in an online TCGA database (n = 160 for normal liver tissue, n = 369 for tumor tissue; 1-way analysis of variance). ∗P < .05. (E, J, and O) The expression of FAP, CD29, and periostin in different tumor stages of CCA (n = 36, 1-way analysis of variance). (G, L, and Q) The expression of FAP, CD29, and periostin in different tumor stages of HCC (n = 369, 1-way analysis of variance). (H, M, and R) Overall survival assessed using the online TCGA database at www.gepia.com. The differences in survival related to CAF markers CD29, FAP, and periostin messenger RNA expression were compared in each group involving all patients (Log-rank test, FAP [n = 36 for CCA, n = 358 for HCC]; CD29 [n = 36 for CCA, n = 364 for HCC]; periostin [n = 36 for CCA, n = 364 for HCC]). Dotted line indicates the 95% CI. HR, hazard ratio; N, normal liver tissue; T, tumor tissue.