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. 2020 Sep 12;11(2):407–431. doi: 10.1016/j.jcmgh.2020.09.003

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Supernatant of organoids on the growth, morphology, and gene expression of CAFs. (A and B) Growth of mouse CAFs in the presence or absence of organoid conditioned medium (n = 9). (C and D) Growth of human CAFs in the presence or absence of organoid conditioned medium (n = 9). (E) Expression profile of mouse CAFs markers in the presence or absence of organoid conditioned medium (n = 8). (F) Expression profile of human CAF markers in the presence or absence of organoid conditioned medium (n = 8). (B and D–F) Data are presented as means ± SD. Mann–Whitney U tests. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001. CTR, control; CON, conditioned; FSP1, fibroblast-specific protein 1; hCAF, human cancer associated fibroblast; hOR, human organoid; mCAF, mouse cancer associated fibroblast; mOR, mouse organoid.