. 2020 Oct 31;11(2):449–464. doi: 10.1016/j.jcmgh.2020.10.012

Table 1.

Features for Common TP53 Mutations in BE Progression Samples

Codon	Exon	Protein Folding^a	Residue Function^b	Dominant Negative^b	Structural Motif^b	Mutation Type^c
C135	5-exon	NA	Buried	Moderate	L1/S/H2	Loss
R175	5-exon	mostly unfolded	Buried	Yes	L2/L3	NA
R213	6-exon	nonsense	Buried	NA	NDBL/beta-sheets	NA
G245	7-exon	NA	Buried	Yes	L2/L3	Loss
R248	7-exon	mostly folded	DNA binding	Yes	L2/L3	Loss
R273	8-exon	mostly folded	DNA binding	Yes	L1/S/H2	Loss
R282	8-exon	mostly unfolded	Buried	Moderate	L1/S/H2	NA

NA, not available.

From Muller et al (experimental)⁴⁰ and Bullock et al (predictive).¹⁰⁵

From International Agency for Research on Cancer TP53 database (https://p53.iarc.fr).¹⁰⁶

From Jordan et al.¹⁰⁷