Figure 4.

L-PK alters mitochondrial and metabolic pathways in a male-specific manner. (A) Principal component analyses, a data reduction method, summarize total gene expression in livers from males and females expressing green fluorescent protein or L-PK in 2 dimensions. (B–D) Global genome-wide transcriptomics of livers from females or males that were expressing green fluorescent protein or L-PK (n = 4 per group) along with their respective pathway enrichments by DAVID and ToppGene analyses. Males are in blue, and females are in red; green fluorescent protein expression is in light color, and L-PK expression is in dark color. P values were calculated by DESeq function of Bioconductor R-package. OEx, overexpressing.