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. 2020 Sep 14;11(2):389–406. doi: 10.1016/j.jcmgh.2020.09.004

Figure 6.

Figure 6

L-PK is causal in developing insulin resistance. Eight-week-old male C57BL/6J mice were injected with either loss-of-function (shffLuc or shPklr) or gain-of-function (green fluorescent protein or PKLR) AAV8-TBG vectors and then fed HF/HS diet for 17 weeks. Comparisons of (A and E) GTT, (B and F) ITT, (C and G) L/PTT, and (D and H) homeostatic model assessment of insulin resistance measures of L-PK silencing (KD) or overexpressing (OEx) mice, respectively. Data are presented as mean ± SEM (n = 7–8 mice per group). ∗P < .05; ∗∗P < .01 by (A–C and E–G) two-factor analysis of variance with Holm-Sidak’s post hoc test; (D and H) t test. ∗∗∗P < .001.