Table 1.
Clinical and Biochemical Characteristics of Subjects With Gene Expression Data (N = 144) Shown in Figure 1
| Characteristics | Non-NASH (n = 87) | NASH (n = 57) | P value |
|---|---|---|---|
| Age (y) | 37.0 (30.0–46.0) | 39.0 (34.0–47.0) | .472 |
| Sex (male %) | 13 (14.9) | 12 (21.1) | .344 |
| BMI (kg/m2) | 41.0 (37.9–45.9) | 43.7 (38.9–48.8) | .319 |
| Fasting glucose (mg/dL) | 89.0 (80.0–99.0) | 94.0 (86.0–100.0) | .172 |
| Fasting insulin (μU/L) | 9.6 (6.1–12.7) | 14.5 (11.3–18.5) | 2.2E-04 |
| HOMA-IR | 2.1 (1.5–3.1) | 3.3 (2.5–4.2) | .001 |
| Triglycerides (mg/dL) | 120.8 (89.5–153.0) | 161.5 (110.0–219.0) | 2.7E-04 |
| Total cholesterol (mg/dL) | 168.5 (147.5–194.8) | 172.0 (148.0–204.8) | .799 |
| HDL-C (mg/dL) | 36.0 (32.0–44.0) | 34.5 (31.0–41.0) | .140 |
| AST (IU/mL) | 26.0 (20.3–31.0) | 29.5 (25.0–36.3) | .016 |
| ALT (IU/mL) | 26.0 (18.0–35.0) | 28.5 (23.0–41.8) | .024 |
| GGT (IU/mL) | 16.5 (13.0–24.8) | 23.0 (18.0–32.8) | 2.4E-04 |
NOTE. Data are shown as median (interquartile range) or n (%) according to distribution of variables. Data were analyzed using Mann-Whitney U or χ2 test. P values in bold indicate significant differences.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment for insulin resistance.