Table 1.

Incidence rate ratios and 95% CIs for the impact of time and the proportion of DOAC items prescribed on hospitalised AF-related stroke incidence

	All strokes*	Ischaemic strokes*	Haemorrhagic strokes*
Year†	1.08 (1.06 to 1.10)	1.12 (1.09 to 1.15)	1.07 (0.99 to 1.14)
DOAC proportion	0.91 (0.84 to 0.98)	0.93 (0.86 to 0.99)	0.99 (0.74 to 1.33)

*Defined as stroke as the primary diagnosis and AF as the secondary diagnosis recorded in the Hospital Episode Statistics database. Each model was adjusted for annual AF prevalence, and each CCG was included as a random intercept to account for between-CCG variation.

†Year was included as a continuous variable.

AF, atrial fibrillation; DOAC, direct oral anticoagulant.