Table 3:

Analyses of accuracy and speed Z scores for each Penn Computerized Neurocognitive Battery test, including psychosis factor score as a covariate for speed, and psychosis and depression factor scores as covariates for accuracy

	Executive function			Episodic memory		Complex cognition (NVR)	Social cognition		Motor (SM)
	ATT	WM	PS	FMEM	AM		EID	EDI
Accuracy
Major depressive disorder
Estimate	−0·494*	−0·386*	−0·307*	−0·204*	−0·229*	−0·114*	−0·209*	−0·273*	NA
p value	9·3 × 10−14*	8·6 × 10−10*	5·1 × 10−10*	7·2 × 10·0−06*	5·6 × 10−07*	0·012*	6·9 × 10−05*	6·5 × 10−08*	NA
Bipolar 2 disorder
Estimate	−0·489*	−0·371*	−0·348*	−0·124	−0·226*	−0·048	−0·297*	−0·337*	NA
p value	1·1 × 10−05*	0·00049*	3·2 × 10−05*	0·11	0·0035*	0·53	0·00098*	0·00011*	NA
Bipolar 1 disorder
Estimate	−0·689*	−0·695*	−0·809*	−0·343*	−0·375*	−0·272*	−0·294*	−0·368*	NA
p value	1·5 × 10−18*	3·7 × 10−19*	6·5 × 10−41*	3·6 × 10−10*	7·2 × 10−12*	7·1 × 10−07*	3·1 × 10−06*	1·5 × 10−09*	NA
Schizophrenia
Estimate	−1·074*	−0·780**	−0·769*	−0·301*	−0·411*	−0·275*	−0·126	−0·386*	NA
p value	3·3 × 10−09*	1·1 × 10−05*	1·2 × 10−08*	0·016*	0·00096*	0·028*	0·38	0·0057*	NA
Psychosis
Estimate	−0·159*	−0·006	−0·158*	−0·080*	−0·062	−0·068	−0·096*	−0·066	NA
p value	0·0043*	0·92	0·00016*	0·038*	0·11	0·079	0·03*	0·12	NA
Depression
Estimate	−0·016	0·088	−0·014	0·007	0·022	0·023	0·239*	0·061	NA
p value	0·75	0·076	0·72	0·84	0·52	0·52	5·8 × 10−09*	0·12	NA
Male
Estimate	0·009	0·134	−0·012	−0·058	0·051	0·169*	−0·327*	−0·091	NA
p value	0·91	0·094	0·84	0·31	0·38	0·0033*	9·2 × 10−07*	0·16	NA
Speed
Major depressive disorder
Estimate	−0·484*	−0·516*	−0·293*	−0·213*	0·073	0·015	−0·186*	−0·037	−0·571*
p value	5·7 × 10−17*	9 × 10−21*	1·8 × 10−06*	4·9 × 10−05*	0·13	0·75	0·0015*	0·48	1·2 × 10−21*
Bipolar 2 disorder
Estimate	−0·464*	−0·230*	−0·524*	−0·168	−0·074	−0·187*	−0·310*	−0·143	−0·615*
p value	3·2 × 10−06*	0·016*	9·9 × 10−07*	0·068	0·38	0·024*	0·0026*	0·12	4 × 10−09*
Bipolar 1 disorder
Estimate	−0·878*	−0·531*	−0·933*	−0·488*	−0·088	−0·218*	−0·762*	−0·418*	−1·003*
p value	2·3 × 10−35*	1·3 × 10−14*	3·2 × 10−34*	3·3 × 10−14*	0·13	0·00021*	1·1 × 10−25*	7·3 × 10−11*	1·4 × 10−41*
Schizophrenia
Estimate	−0·928*	−0·765*	−0·831*	−0·361*	−0·114	−0·173	−1·097*	−0·196	−0·806*
p value	7·5 × 10−09*	9·3 × 10−07*	9·8 × 10−07*	0·012*	0·39	0·19	1·7 × 10−11*	0·18	8·3 × 10−07*
Psychosis
Estimate	−0·126*	−0·075	−0·154*	−0·054	0·002	0·019	−0·091	−0·176*	−0·243*
p value	0·0092*	0·11	0·0029*	0·22	0·96	0·65	0·062	5·9 × 10−05*	8·3 × 10−07*
Male
Estimate	0·348*	0·383*	0·000	0·019	0·064	−0·006	−0·187*	−0·081	0·216*
p value	3·1 × 10−06*	1·2 × 10−07*	1	0·78	0·31	0·93	0·015*	0·23	0·0056*

ATT=Continuous Performance Test. WM=Letter-N-Back test. PS=Digit Symbol Test, matching trials. FMEM=Face Memory test. AM=Digit Symbol test, recall trials. NVR=Matrix Analysis test. EID=Emotion Identification test. EDI=Measured Emotion Differentiation test. SM=Motor Praxis test. NA=not applicable.

^*Nominal p<0·05.