Figure 6.

IGFBP5 expression, determining its association with MN1 levels in gliomas. (A) Graphical summary of relative IGFBP5 expression in LGGs (n = 13) and HGGs (n = 27) of the experimental dataset. The central bar and whiskers denote mean (±SD). Linear regression plots to test the association of IGFBP5 expression with MN1 expression levels in (B) LGGs (n = 11), and (C) HGGs (n = 27). (D) Pirate plots showing IGFBP5 expression (log transformed RNAseq median values) in LGGs (n = 249) and HGGs (n = 417) from the TCGA datasets. Scatter plots show the relatedness of IGFBP5 expression with MN1 expression levels in (E) LGGs (n = 249) and (F) HGGs (n = 417). The black regression line represents the regression model fitted to the data, and ‘R²’ refers to the coefficient of determination. Statistical test values comparing gene expression between the glioma grades are indicated above the respective plots.