Fig. 3.
Effect of ETA receptor blockade on blood pressure during renal medullary GPER1 activation in female ETB def rats. MAP was measured during two 20-minute urine collection periods in anesthetized female ETB def rats or TG control rats: at baseline during the intramedullary infusion of vehicle and 20 minutes after the infusion of the GPER1 agonist G1 (5 pmol/kg per minute) was initiated. ETA receptor blockade was achieved by intravenous bolus injection of ABT-627 (5 mg/kg) 30 minutes before the beginning of the baseline urine collection period in female ETB def rats; TG and ETB def controls received intravenous bolus injections of vehicle. Each line shows data for an individual animal. Statistical comparisons were performed by repeated-measures two-way ANOVA followed by Dunnett’s post hoc tests.