Table 2. . Epigenome-wide significant CpG sites among non-injection observations.
| CpG | Chr | Position | Nearest gene | Position to gene | logFC | Average M value | t | p-value | Bonferroni p-value |
|---|---|---|---|---|---|---|---|---|---|
| cg12051710 | 12 | 2989070 | C12orf32 | Body | -0.50 | 3.07 | -8.10 | 8.19E-15 | 7.08E-09 |
| cg07839457† | 16 | 57023022 | NLRC5 | TSS1500 | -1.06 | -1.13 | -7.67 | 1.53E-13 | 1.32E-07 |
| cg13452062† | 1 | 79088559 | IFI44L | 5′UTR | -2.20 | 1.33 | -7.54 | 3.78E-13 | 3.27E-07 |
| cg05696877† | 1 | 79088769 | IFI44L | 5′UTR | -1.75 | 0.41 | -7.35 | 1.26E-12 | 1.09E-06 |
| cg09801824† | 10 | 74076930 | 0.29 | -2.23 | 7.23 | 2.74E-12 | 2.37E-06 | ||
| cg12688661 | 8 | 128975417 | PVT1 | Body | -0.33 | 2.55 | -6.78 | 4.82E-11 | 4.17E-05 |
| cg09921385 | 4 | 7000882 | TBC1D14 | Body | -0.23 | 0.15 | -6.60 | 1.44E-10 | 1.24E-04 |
| cg01538263 | 15 | 74014910 | 0.16 | 1.24 | 6.57 | 1.73E-10 | 1.49E-04 | ||
| cg06756551 | 7 | 137352607 | DGKI | Body | 0.20 | 1.37 | 6.53 | 2.21E-10 | 1.91E-04 |
| cg10771443† | 2 | 7018855 | RSAD2 | Body | -0.64 | -1.63 | -6.42 | 4.11E-10 | 3.55E-04 |
| cg21549285† | 21 | 42799141 | MX1 | 5′UTR | -1.02 | 0.99 | -6.39 | 4.96E-10 | 4.29E-04 |
| cg17633074 | 6 | 30878864 | Body | 0.20 | 1.11 | 6.35 | 6.36E-10 | 5.50E-04 | |
| cg08818049 | 12 | 109085884 | CORO1C | Body | 0.31 | -2.01 | 6.29 | 8.82E-10 | 7.63E-04 |
| cg23387863† | 15 | 77472416 | Body | -0.32 | 1.33 | -6.19 | 1.58E-09 | 1.36E-03 | |
| cg23089225 | 15 | 67440902 | SMAD3 | 5′UTR; Body | 0.21 | -1.56 | 6.09 | 2.78E-09 | 2.41E-03 |
| cg12832157 | 3 | 4885491 | ITPR1 | Body | -0.27 | 2.96 | -6.07 | 3.09E-09 | 2.67E-03 |
| cg22764925 | 22 | 24979964 | GGT1 | 5′UTR | -0.41 | 1.12 | -6.07 | 3.19E-09 | 2.76E-03 |
| cg23473907 | 6 | 3523483 | 0.16 | 0.68 | 6.05 | 3.58E-09 | 3.10E-03 | ||
| cg21670513 | 6 | 43028611 | KLC4 | 5′UTR; TSS1500; Body | 0.29 | 2.81 | 6.03 | 3.97E-09 | 3.43E-03 |
| cg18544413† | 12 | 65019442 | RASSF3 | Body | 0.39 | -3.45 | 5.98 | 5.17E-09 | 4.47E-03 |
| cg18387107 | 12 | 3980774 | PARP11 | 5′UTR; Body | -0.29 | 0.55 | -5.98 | 5.33E-09 | 4.61E-03 |
| cg00959259† | 3 | 122281975 | PARP9 | 5′UTR; TSS1500 | -0.84 | 0.03 | -5.97 | 5.43E-09 | 4.70E-03 |
| cg10140784 | 12 | 48531426 | Body | 0.18 | 2.02 | 5.97 | 5.50E-09 | 4.75E-03 | |
| cg18401376 | 6 | 35141132 | 0.18 | 1.27 | 5.93 | 7.05E-09 | 6.10E-03 | ||
| cg24695011 | 3 | 125781947 | SLC41A3 | Body; 5′UTR | 0.17 | 1.37 | 5.92 | 7.24E-09 | 6.26E-03 |
| cg06798591 | 11 | 94556390 | AMOTL1 | Body | 0.14 | 0.84 | 5.90 | 8.02E-09 | 6.93E-03 |
| cg25127026 | 12 | 96606023 | ELK3 | 5′UTR | 0.39 | -2.91 | 5.90 | 8.18E-09 | 7.07E-03 |
| cg13344385 | 12 | 52642852 | AC021066.1 | 0.15 | 1.17 | 5.88 | 9.04E-09 | 7.81E-03 | |
| cg21139291 | 11 | 6425839 | APBB1 | 5′UTR; 1stExon; Body | 0.14 | 0.05 | 5.87 | 9.44E-09 | 8.16E-03 |
| cg23469117 | 22 | 21985646 | YDJC | TSS1500 | 0.16 | 1.18 | 5.84 | 1.15E-08 | 9.93E-03 |
| cg14030069 | 20 | 48037535 | Body | 0.17 | 1.07 | 5.83 | 1.21E-08 | 1.05E-02 | |
| cg20474403 | 1 | 110599939 | RP4-773N10.4 | 0.20 | 2.25 | 5.82 | 1.27E-08 | 1.10E-02 | |
| cg22485390‡ | 12 | 53089322 | RP11-641A6.3 | Body | 0.23 | 2.47 | 5.74 | 1.93E-08 | 1.67E-02 |
| cg10129948 | 11 | 57085849 | Body | 0.16 | 1.92 | 5.73 | 2.09E-08 | 1.81E-02 | |
| cg22862003†‡ | 21 | 42797588 | MX1 | TSS1500; 5′UTR | -0.56 | 0.54 | -5.73 | 2.13E-08 | 1.84E-02 |
| cg14193087 | 19 | 18614252 | Body | 0.19 | -1.96 | 5.72 | 2.25E-08 | 1.94E-02 | |
| cg11504739 | 11 | 62186060 | SCGB1A1 | TSS1500 | 0.22 | 2.15 | 5.72 | 2.25E-08 | 1.95E-02 |
| cg09381237 | 11 | 86178666 | ME3 | Body | 0.25 | 2.24 | 5.71 | 2.27E-08 | 1.97E-02 |
| cg17986793 | 21 | 42797899 | MX1 | TSS200; 5′UTR | -0.49 | -2.61 | -5.69 | 2.56E-08 | 2.21E-02 |
| cg15839328‡ | 2 | 7018885 | RSAD2 | Body | -0.60 | -1.56 | -5.68 | 2.79E-08 | 2.41E-02 |
| cg03834031 | 22 | 46465717 | RP6-109B7.4 | -0.19 | -1.79 | -5.67 | 2.90E-08 | 2.51E-02 | |
| cg16985233 | 15 | 43806249 | -0.21 | 3.93 | -5.66 | 3.11E-08 | 2.69E-02 | ||
| cg05883128‡ | 4 | 169239131 | DDX60 | 5′UTR | -0.36 | -0.38 | -5.64 | 3.44E-08 | 2.97E-02 |
| cg23389199 | 1 | 223205670 | 0.16 | 1.60 | 5.62 | 3.69E-08 | 3.19E-02 | ||
| cg17130481 | 20 | 853509 | ANGPT4 | 3′UTR | 0.12 | 0.58 | 5.62 | 3.84E-08 | 3.32E-02 |
| cg05552874 | 10 | 91153143 | Body | -0.53 | 0.83 | -5.62 | 3.85E-08 | 3.33E-02 | |
| cg05293861 | 12 | 4262708 | -0.36 | -4.68 | -5.62 | 3.85E-08 | 3.33E-02 | ||
| cg21222743† | 6 | 31543545 | TNF | 1st Exon | 0.43 | -3.26 | 5.58 | 4.55E-08 | 3.93E-02 |
| cg07613362 | 19 | 16462176 | -0.19 | 1.54 | -5.56 | 5.09E-08 | 4.40E-02 |
†
Also significant in injection visit EWAS.
‡
Probe that contains a common SNP.
EWAS: Epigenome-wide association study; SNP: Single-nucleotide polymorphism.