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. 2020 Oct 12;30(12):2002–2007. doi: 10.1136/ijgc-2020-001929

Figure 1.

Figure 1

Study design PORTEC-4a trial. Reprinted from 'Molecular-integrated risk profile to determine adjuvant radiotherapy in endometrial cancer: evaluation of the pilot phase of the PORTEC-4a trial' by Wortman et al., 2018, Gynecologic Oncology 151; 69–75. A: trial design of the PORTEC-4a trial; B: decision tree for the molecular-integrated profile; CTNNB1, β-catenin; EBRT, external beam radiotherapy; LVSI; lymph-vascular space invasion; HIR, high-intermediate risk; L1-CAM, L1-cell adhesion molecule; POLE, polymerase-ɛ * stage I (with invasion) disease, grade 3 tumor; stage IB disease, grade 1 or 2 tumor, with either age 60 years or older or substantial LVSI; stage IB disease, grade 3 tumor, without LVSI; or stage II (microscopic) disease, grade 1 tumor.