Table 2. Multivariate Predictors of BARC Types 3 to 5 Bleeding and MI and/or ST at 365 Days.
| Predictor | BARC types 3-5 bleeding | MI and/or ST | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Aged ≥65 y | 1.50 (1.08-2.08) | .01 | NA | NA |
| Diabetes (requiring treatment with either insulin or oral medication) | NA | NA | 1.56 (1.26-1.93) | <.001 |
| Prior MI | NA | NA | 1.89 (1.52-2.35) | <.001 |
| Liver disease, cancer, or surgerya | 1.63 (1.27-2.09) | .0001 | NA | NA |
| COPD | 1.39 (1.05-1.83) | .02 | NA | NA |
| Current smoker | 1.47 (1.08-1.99) | .01 | 1.48 (1.09-2.01) | .009 |
| NSTEMI or STEMI presentation | NA | NA | 1.82 (1.46-2.25) | <.001 |
| Hemoglobin, g/dL | ||||
| ≥13 | 1 [Reference] | <.001 | 1 [Reference] | .005 |
| 11-12.9 | 1.69 (1.30-2.20) | 1.27 (0.99-1.63) | ||
| <11 | 3.99 (3.06-5.20) | 1.50 (1.12-1.99) | ||
| eGFR, mL/min | ||||
| ≥60 | 1 [Reference] | .02 | 1 [Reference] | .001 |
| 30-59 | 0.99 (0.79-1.24) | 1.30 (1.03-1.66) | ||
| <30 | 1.43 (1.04-1.96) | 1.69 (1.20-2.37) | ||
| Complex procedureb | 1.32 (1.07-1.61) | .008 | 1.50 (1.21-1.85) | <.001 |
| Bare metal stentc | NA | NA | 1.53 (1.23-1.89) | <.001 |
| OAC at discharge | 2.00 (1.62-2.48) | <.001 | NA | NA |
| C statistic | 0.68 | NA | 0.69 | NA |
Abbreviations: ARC, Academic Research Consortium; BARC, Bleeding Academic Research Consortium; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; HR, hazard ratio; MI, myocardial infarction; NA, not applicable; NSTEMI, non–ST-segment elevation MI; OAC, oral anticoagulants; ST, definite or probable stent thrombosis; STEMI, ST-segment elevation MI.
SI conversion factor: To convert hemoglobin to grams per liter, multiply by 10.0.
a
At least 1 of 3 modified ARC high bleeding risk criteria (cancer, severe liver disease, and planned major surgery; eTable 1 in the Supplement).
b
As defined by Giustino et al.31
c
Compared with drug-eluting stents or drug-coated stents.