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. Author manuscript; available in PMC: 2021 Jan 7.
Published in final edited form as: Nature. 2020 Apr 8;580(7805):647–652. doi: 10.1038/s41586-020-2174-3

Figure 2. Lack of Gasdermin-D activation drives anxiety-like behaviors in mice.

Figure 2.

(a-d) Anxiety-related behaviors were assessed in adult (8–12 weeks old) WT, Il1r−/−, Il18r−/−, Myd88−/−, Gsdmd−/−, and Casp11−/− mice using the elevated plus maze. (a-b) Quantification of (a) time spent in the open arms (o) and (b) distance traveled (WT n=21, Il1r−/− n=19, Il18r−/− n=22, Myd88−/− n=16; from 4 independent experiments). (c) Time spent in the open arms of the elevated plus maze and (d) total distance traveled during testing (WT n=24, Gsdmd−/− n=14, Casp11−/− n=10; from 2 independent experiments). All n values refer to the number of mice used. Error bars depict mean ± s.e.m. Statistics calculated by one-way ANOVA with Tukey’s post hoc tests.