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. Author manuscript; available in PMC: 2021 Jan 7.
Published in final edited form as: Nature. 2020 Apr 8;580(7805):647–652. doi: 10.1038/s41586-020-2174-3

Extended Data Figure 1. Molecular components of the AIM2 inflammasome are abundantly expressed in the brain during neurodevelopment.

Extended Data Figure 1.

(a-c) Brains from (a) p5 and (b) p21 WT mice were evaluated for the mRNA expression of inflammasome component genes (red) Casp1 (p5 n=4, p21 n=2), Aim2 (p5 n=3, p21 n=2), and Gsdmd (p5 n=3, p21 n=2) using RNA scope. (c) Quantification of Casp1 (p5 n=4, p21 n=2), Aim2 (p5 n=3, p21 n=2), and Gsdmd (p5 n=3, p21 n=2) mRNA puncta in the hippocampus per 40X image; from 1 experiment. Error bars depict mean ± s.e.m. n values refer to biological replicates.