Table 3. Changes in V_T, K₁, and k₂ after P-gp Inhibition in Brain Regions using 30 and 91 min Scan Durations and 1-TCM^a.

scan duration	regions	K1 ± SE (%)	p values	VT ± SE (%)	p values	k2 ± SE (%)	p values
% of Changes between Baseline and after-Inhibition Scan in 30 min Scan
30 min	basal ganglia	156 ± 45	<0.001	244 ± 38	<0.001	–25 ± −4	<0.001
	brainstem	176 ± 46	<0.001	241 ± 33	<0.001	–19 ± −2	0.008
	cerebellum	141 ± 37	<0.001	276 ± 42	<0.001	–35 ± −4	<0.001
	cingulate cortex	138 ± 32	<0.001	294 ± 41	<0.001	–40 ± −4	<0.001
	orbitofrontal cortex	93 ± 28	<0.001	190 ± 39	<0.001	–33 ± −3	<0.001
	hippocampus	146 ± 35	<0.001	227 ± 32	<0.001	–25 ± −3	<0.001
	hypothalamus	158 ± 44	<0.001	270 ± 39	<0.001	–30 ± −4	<0.001
	insular cortex	152 ± 38	<0.001	294 ± 36	<0.001	–35 ± −5	<0.001
	midbrain	205 ± 57	<0.001	305 ± 49	<0.001	–25 ± −4	<0.001
	occipital cortex	130 ± 29	<0.001	268 ± 35	<0.001	–37 ± −4	<0.001
	parietal cortex	127 ± 31	<0.001	247 ± 34	<0.001	–34 ± −4	<0.001
	striatum	168 ± 45	<0.001	267 ± 40	<0.001	–27 ± −3	<0.001
	temporal cortex	143 ± 41	<0.001	242 ± 39	<0.001	–28 ± −4	<0.001
	thalamus	176 ± 41	<0.001	285 ± 33	<0.001	–28 ± −4	<0.001
	white matter	145 ± 36	<0.001	268 ± 38	<0.001	–33 ± −4	<0.001
	whole brain	136 ± 34	<0.001	252 ± 37	<0.001	–33 ± −4	<0.001
% of Changes between Baseline and after-Inhibition Scan in 91 min Scan
91 min	basal ganglia	174 ± 46	<0.001	210 ± 42	<0.001	–11 ± −1	0.059
	brainstem	199 ± 48	<0.001	199 ± 32	<0.001	1 ± 0	0.855
	cerebellum	167 ± 41	<0.001	231 ± 43	<0.001	–18 ± −2	0.013
	cingulate cortex	166 ± 37	<0.001	237 ± 43	<0.001	–21 ± −2	0.041
	orbitofrontal cortex	111 ± 30	<0.001	153 ± 40	<0.001	–16 ± −2	0.049
	hippocampus	162 ± 37	<0.001	198 ± 35	<0.001	–13 ± −2	0.160
	hypothalamus	184 ± 46	<0.001	215 ± 43	<0.001	–9 ± −1	0.224
	insular cortex	177 ± 40	<0.001	246 ± 43	<0.001	–19 ± −2	0.004
	midbrain	228 ± 62	<0.001	267 ± 52	<0.001	–11 ± −2	0.314
	occipital cortex	155 ± 34	<0.001	221 ± 34	<0.001	–20 ± −2	0.018
	parietal cortex	148 ± 34	<0.001	204 ± 36	<0.001	–18 ± −2	0.076
	striatum	193 ± 47	<0.001	220 ± 41	<0.001	–8 ± −1	0.293
	temporal cortex	165 ± 43	<0.001	199 ± 41	<0.001	–10 ± −1	0.112
	thalamus	200 ± 43	<0.001	243 ± 39	<0.001	–12 ± −1	0.222
	white matter	170 ± 39	<0.001	223 ± 41	<0.001	–16 ± −2	0.094
	whole-brain	159 ± 37	<0.001	208 ± 40	<0.001	–15 ± −2	0.072

^aMean values ± SE are listed, changes are shown as percentages.