Figure 13.

Particle synthesis via SAW or SRBW nebulization. The top row reports particle size distributions that confirm production of a) 100 nm order polymer nanoparticles comprising a cluster of sub‐50‐nm aggregates (see insets), and b) crumpled GO nanoparticles and microparticles, simply by nebulizing solutions comprising the polymer or GO suspension, respectively. Also shown in (c) is evidence through confocal microscopy sectioning of the possibility of simultaneously encapsulating, in this case, a fluorescent protein, within the polymer particles. d) The bottom row shows a schematic of the experimental setup (left) for the synthesis of multilayer polymer nanocapsules by nebulizing a polymer solution (in this case, chitosan), collecting the dried particles in a complementary polymer solution of opposite charge (in this case, carboxymethylcellulose [CMC]),and renebulizing over many cycles (one cycle per layer); each layer as well as the plasmid DNA (pDNA) encapsulated within them was verified from the alternating‐zeta potentials measured after the formation of each layer (right). a,b) Reproduced with permission.^{[ 151 ]} Copyright 2008, IOP Publishing Ltd; c) Reproduced with permission.^{[ 153 ]} Copyright 2009, American Institute of Physics; d) Reproduced with permission.^{[ 155 ]} Copyright 2011, American Chemical Society.