Table 1. Evaluation of cytotoxic effect of tofacitinib on fibroblast cell lines by time and concentration.

Tofacitinib	Viability (Percentage of the control)			P
	24 hours	48 hours	72 hours
	Mean±SD	Mean±SD	Mean±SD
Control	100	100	100	-
25 nM	103.0±7.6	96.0±4.5	105.0±3.2	-
50 nM	99.6±6.8*	89.7±6.1**	124.5±5.6**	<0.05
100 nM	78.9±8.2*	73.1±5.6**	98.6±7.6**	<0.05
200 nM	71.8±5.9*	47.4±48*	89.8±5.3**	<0.05
400 nM	56.8±6.4*	25.4±4.2*	71.0±4.1**	<0.05
800 nM	39.7±7.6*	14.8±4.1*	49.6±48**	<0.05
SD: Standard deviation; * p<0.05; ** p<0.05.