Table 2.
Genes associated with lung radiation toxicity
| Study | Gene associated with lung toxicity year | Gene function | References | |
|---|---|---|---|---|
| Pu et al. | 2014 | RPCDC2 (rs10711) and (rs1871445) DDX58 (rs11795343) and (rs7865082) FGF5 (rs3733336) | Inflammation | [87] |
| ETS2 (rs2298560) LIMS1 (rs12469016) | ||||
| GHR (rs4292454) TFEB (rs13202921) | ||||
| Wen et al. | 2014 | RP LIN28B (rs314280) | RNA binding protein | [88] |
| LIN28B (rs314276) | ||||
| Pang et al. | 2013 | HSPB1 (rs2868371) | Oxidative stress pathways | [89] |
| Xiong et al. | 2013 | ATM (rs189037) and (rs228590) | DNA repair | [90] |
| Kelsey et al. | 2013 | XRCC1 (rs25487) DNA repair BRCA1 (rs16942) | DNA repair | [91] |
| Mak et al. | 2012 | MTHFR (rs1801131) | Oxidative stress pathways | [92] |
| Xu et al. | 2015 | LIG4 (rs1805388) | DNA repair | [93] |
| Yin et al. | 2012 | VEGF (rs2010963) and (rs3025039) | Angiogenesis | [94] |
| Niu et al. | 2012 | TGF-β1 (rs11466345) | Inflammation | [95] |
| Wang et al. | 2008 | P53 Arg72Pro | Cell-cycle regulation, apoptosis, and DNA repair | [96] |
| Hildebrandt et al. | 2010 | RPIL1A (rs1800587/rs17561) IL-8 (rs4073) | Inflammation | [97] |
| TNF (rs1799724) TNFRSF1B (rs1061622) | ||||
| MIF (rs7555622) IL4 (rs2243250) IL4R | ||||
| (rs2070874) IL13 (rs10800925) IL13 (rs20541) | ||||
| NFKBIA (rs1799983) NOS3 (rs1799983) | ||||
| Zhang et al. | 2010 | ATM (rs189037) and (rs373759) | DNA repair | [98] |
| Yuan et al. | 2009 | TGF-β1 (rs1982073) | Inflammation | [99] |
Transforming growth factor-beta 1 (TGF-β1), Deoxyribonucleic-acid (DNA), Ribonucleic-acid (RNA)