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. 2021 Jan 6;18:17. doi: 10.1186/s12974-020-02064-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The antisense miR-142-5p alleviates the PTSD-like behavior in rats exposed to the SPS procedure. a The procedure and timeline of PTSD experiments. b RT-qPCR detection of relative expression of miR-142 in rat hippocampus at different time points. c The relative expression miR-142 in rat hippocampus tested by RT-qPCR two weeks after LV-anti-miR-142 administration. d The immobility time in FST. e Open arm time and f open arm entries in the EPM test. g Representative tracts on day 5 during navigation trials, h the mean escape latency during the five training days, and i the percentage of time spent in the target quadrant in the MWM test. j Total distance, k distance in the central area, and l the percentage of time spent in the center of rats in the OF test. n = 6 rats per genotype. Bar graphs represent the mean ± SEM of independent experimental triplicates. One-way or two-way ANOVA followed by Bonferroni’s post hoc test; *P < 0.05, **P < 0.01