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. 2021 Jan 6;18:1. doi: 10.1186/s12989-020-00396-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Variability of resting membrane potential following exposure to Co₃O₄-NPs. a) Representative 20 s V_r time courses recorded in un-stimulated patch clamped cells belonging to the three experimental groups, previously conditionally paced at 5 Hz for 8 s; b) frequency distributions of V_r (50 sub-intervals of the entire V_r range) with superimposed normal fitting (solid lines). The difference between the number of samples for each interval and that expected from the normal fitting (Δn) is marked in grey; c) mean values ± SEM of Δn, in CTRL, NPc₅, and NPc₅₀ groups. *, p< 0.05 vs CTRL (Kruskal-Wallis non-parametric statistical test followed by U-Mann Whitney test)